AI-Augmented CMC · Pre-Lab Documentation
We compress the slow, expensive work between a promising candidate molecule and a CDMO-ready synthesis package — generating literature-grounded retrosynthetic options, flagging known risk patterns, and producing auditable pre-lab documentation. Assistive by design, human-governed at every gate. Pre-validation; our first benchmark metrics publish in Month 11.
Blind Digital Shadow validation underway
Append-only, SHA-256-chained reasoning trail
Mandatory approval gate before any output
Four functions that compress the candidate-to-CDMO handoff — literature-bound, traceable, and built to be audited
Structured route options drawn from published literature, with every claim traceable to a source
Known failure patterns surfaced: genotoxic impurity classes, scale-up failure modes, stereochemistry concerns, missing analytical controls
Consistent, structured pre-lab packages a CDMO can quote and a reviewer can audit
SHA-256-chained, append-only logging with a human governance gate before any output becomes a deliverable
Five specialist agents (three shown) adversarially review a candidate's synthesis reasoning — surfacing gaps and risk patterns before wet-lab work begins, as input for expert review.
Validates synthetic routes and mechanism hypotheses against literature
Reviews impurity profiles and analytical method gaps
Flags genotoxic impurity formation risks